Airlines with flights from Panama City to Guayaquil
There are two airlines with scheduled flights between PTY and GYE. Copa Airlines is the only airline with non-stop flights from Tocumen International to Simon Bolivar International and the flight time is 2 hours and 15 minutes.
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Schedules

Non-stop with Copa Airlines
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Total flight time: 2 hours and 15 minutes
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Panama City is a Copa Airlines hub.
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35 flights per week
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Boeing 737MAX 9 PassengerBoeing 737-800 PassengerBoeing 737-700 Passenger
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Business class available
PTY
Direct
GYE
W10, Mar 03 - Mar 09
Flight
Mon
Mar 3
Tue
Mar 4
Wed
Mar 5
Thu
Mar 6
Fri
Mar 7
Sat
Mar 8
Sun
Mar 9
CM273
09:01
09:01
09:01
09:01
09:01
09:01
09:01
CM258
11:31
11:31
11:31
11:31
11:31
11:31
11:31
CM378
15:19
15:19
15:19
15:19
15:19
15:19
15:19
CM468
15:37
----
15:37
----
15:37
15:37
15:37
CM213
18:25
18:25
18:25
18:25
18:25
18:25
18:25
CM301
21:25
21:25
21:25
21:25
21:25
21:25
21:25
The timetable & schedule information was updated at 2025-02-17

Via Bogota with AVIANCA
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Total flight time: 5h 07m - 7h 30m.
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15 flights per week
PTY
Via BOG
GYE
W10, Mar 03 - Mar 09
Flight
Mon
Mar 3
Tue
Mar 4
Wed
Mar 5
Thu
Mar 6
Fri
Mar 7
Sat
Mar 8
Sun
Mar 9
AV41
AV77
AV77
03:19
----
03:19
----
03:19
----
03:19
AV41
AV8385
AV8385
03:19
03:19
03:19
03:19
03:19
03:19
03:19
AV323
AV8399
AV8399
----
----
----
----
11:20
----
----
AV59
AV8383
AV8383
----
----
11:25
----
----
----
----
AV642
AV635
AV635
----
13:30
----
13:30
----
13:30
13:30
AV317
AV8399
AV8399
15:34
----
15:34
----
----
----
----
AV61
AV8391
AV8391
----
17:25
----
17:25
----
17:25
----
AV61
AV8371
AV8371
----
----
----
17:25
----
17:25
----
AV61
AV91
AV91
----
17:25
----
----
----
----
----
AV89
AV8391
AV8391
18:30
----
18:30
----
18:30
----
18:30
The timetable & schedule information was updated at 2025-02-17

Via San Jose with AVIANCA
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Total flight time: 6h 50m - 7h 20m.
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4 flights per week
PTY
Via SJO
GYE
W10, Mar 03 - Mar 09
Flight
Mon
Mar 3
Tue
Mar 4
Wed
Mar 5
Thu
Mar 6
Fri
Mar 7
Sat
Mar 8
Sun
Mar 9
AV41
AV77
AV77
03:19
----
03:19
----
03:19
----
03:19
AV41
AV8385
AV8385
03:19
03:19
03:19
03:19
03:19
03:19
03:19
AV323
AV8399
AV8399
----
----
----
----
11:20
----
----
AV59
AV8383
AV8383
----
----
11:25
----
----
----
----
AV642
AV635
AV635
----
13:30
----
13:30
----
13:30
13:30
AV317
AV8399
AV8399
15:34
----
15:34
----
----
----
----
AV61
AV8391
AV8391
----
17:25
----
17:25
----
17:25
----
AV61
AV8371
AV8371
----
----
----
17:25
----
17:25
----
AV61
AV91
AV91
----
17:25
----
----
----
----
----
AV89
AV8391
AV8391
18:30
----
18:30
----
18:30
----
18:30
The timetable & schedule information was updated at 2025-02-17

Via Medellin with AVIANCA
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Total flight time: 4h 31m - 7h 25m.
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2 flights per week
PTY
Via MDE
GYE
W10, Mar 03 - Mar 09
Flight
Mon
Mar 3
Tue
Mar 4
Wed
Mar 5
Thu
Mar 6
Fri
Mar 7
Sat
Mar 8
Sun
Mar 9
AV41
AV77
AV77
03:19
----
03:19
----
03:19
----
03:19
AV41
AV8385
AV8385
03:19
03:19
03:19
03:19
03:19
03:19
03:19
AV323
AV8399
AV8399
----
----
----
----
11:20
----
----
AV59
AV8383
AV8383
----
----
11:25
----
----
----
----
AV642
AV635
AV635
----
13:30
----
13:30
----
13:30
13:30
AV317
AV8399
AV8399
15:34
----
15:34
----
----
----
----
AV61
AV8391
AV8391
----
17:25
----
17:25
----
17:25
----
AV61
AV8371
AV8371
----
----
----
17:25
----
17:25
----
AV61
AV91
AV91
----
17:25
----
----
----
----
----
AV89
AV8391
AV8391
18:30
----
18:30
----
18:30
----
18:30
The timetable & schedule information was updated at 2025-02-17